Other features which will help the healthcare professionals to decide if the patient needs to go to a specialist unit include: involvement of the brain, abnormal clotting, kidney impairment, low blood pressure (hypotension), low blood sugar (hypoglycaemia) and high blood acid levels.Urgent liver transplantation is the only treatment when overwhelming, irreversible liver failure occurs.See if you are eligible for a free NHS flu jab today.Assess your symptoms online with our free symptom checker.The information on this page is written and peer reviewed by qualified clinicians.Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. Liver damage is minimised with acetylcysteine. The government has made rules to limit how much can be bought in one go, which may help reduce the number of overdoses. 2. Choose one of the access methods below or take a look at our If you have a Best Practice personal account, your own subscription or have registered for a free trial, log in here:If your hospital, university, trust or other institution provides access to BMJ Best Practice through services such as OpenAthens or Shibboleth, log in via this button:If you have been provided an access code, you can register it here:For any urgent enquiries please contact our customer services team who are ready to help with any problems.The entered sign-in details are incorrect. It is reasonably easy to take and so the government had also ruled that it should only be available in blister packs which can mean the tablets are trickier to get out.There may be no symptoms for the first day. Treatment is with intravenous N-acetylcysteine (NAC) and is given to all who have high paracetamol levels.If there is any doubt about the time of the overdose or there has been a 'staggered overdose', intravenous NAC is started without delay.All patients will need to be seen by the psychiatric team before discharge.NAC protects the liver and this may be the result of it restoring the glutathione levels. It is normally found as a 500 mg tablet but it is often combined with other active ingredients in various preparations. The NAPQI can then build up and damage the liver.Coronavirus: how quickly do COVID-19 symptoms develop and how long do they last?Coronavirus: what are asymptomatic and mild COVID-19?Coronavirus: what are moderate, severe and critical COVID-19?What are the differences between colds, flu and COVID-19?COVID-19: how to tell hay fever and coronavirus apartAre any coronavirus home remedies safe or effective?Is losing your sense of taste and smell a symptom of coronavirus?Paracetamol is the most common medicine taken in overdose. Patient does not provide medical advice, diagnosis or treatment.Registered number: 10004395 Registered office: Fulford Grange, Micklefield Lane, Rawdon, Leeds, LS19 6BA. BMJ. They may not intend to kill themselves, and occasionally may not even realise they are harming themselves until they begin to feel unwell.Some people are at increased risk of liver damage from paracetamol. After this, paracetamol is inactivated before being removed from the body. An overdose can also be taken accidentally - for example, toddlers and people with poor eyesight.In some, the act of taking an overdose is a spur-of-the-moment thing, whilst in others it can be pre-planned. doi: 10.1136/bmj.d2218. All rights reserved. This includes:Paracetamol is widely available from shops and is present in most homes. During that period several blood tests may be taken to monitor the liver and kidneys.It is most effective when given within eight hours of taking the paracetamol overdose. It may also help the liver to combat toxicity. Significant overdose can result in liver failure if not promptly treated with the antidote.Paracetamol is usually taken by mouth and is available in various ways, such as in tablet, caplet, soluble and liquid forms. It is a very useful analgesic (alone or in combination) and also is an antipyretic. 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