Reflex … If you are a consumer or patient please visit Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, Store at room temperature. This dose was associated with some maternal toxicity (decreased food consumption and body weights). It must be diluted before administration as an intravenous bolus or continuous intravenous infusion. The Pharmacy Bulk Vial is to be used only in a suitable work area such as a laminar flow hood (or an equivalent clean air compounding area). It also acts as a conjunctival decongestant. Each closure shall be penetrated only one time with a suitable sterile transfer device or dispensing set that allows measured dispensing of the contents. Because of its increasing blood pressure effects, phenylephrine hydrochloride can precipitate angina in patients with severe arteriosclerosis or history of angina, exacerbate underlying heart failure, and increase pulmonary arterial pressure. Adverse reactions reported in published clinical studies, observational trials, and case reports of phenylephrine hydrochloride are listed below by body system. The Pharmacy Bulk Vial is intended for dispensing of single doses to multiple patients in a pharmacy admixture program and is restricted to the preparation of admixtures for infusion. Following phenylephrine hydrochloride intravenous administration, increases in systolic and diastolic blood pressures, mean arterial blood pressure, and total peripheral vascular resistance are observed. The … Care should be taken to avoid extravasation of phenylephrine hydrochloride injection. Follow all instructions closely. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. Clinical studies of phenylephrine hydrochloride did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. No adverse effects on growth and development (learning and memory, sexual development, and fertility) were noted in the offspring of pregnant rats at any dose tested. To view updated drug label links, paste the RSS feed address (URL) shown below into a RSS reader, or use a browser which supports RSS feeds, such as Safari for Mac OS X.If you no longer wish to have this DailyMed RSS service, simply delete the copied URL from your RSS Reader. After intravenous administration of radiolabeled phenylephrine hydrochloride, approximately 80% of the total dose was eliminated within first 12 h; and approximately 86% of the total dose was recovered in the urine within 48 h. The excreted unchanged parent drug was 16% of the total dose in the urine at 48 h post intravenous administration. (Skin and Subcutaneous Necrosis: Extravasation during intravenous administration may cause necrosis or sloughing of tissue. Consider starting at the lower end of the recommended dose range, and adjusting dose based on the target blood pressure goal. Phenylephrine hydrochloride can increase the need for renal replacement therapy in patients with septic shock. The following are the recommended dosages for the treatment of hypotension during anesthesia. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. The onset of blood pressure increase following an intravenous bolus phenylephrine hydrochloride administration is rapid, typically within minutes. There were decreased caudal sperm density and increased abnormal sperm reported in males treated with 3 mg/kg/day phenylephrine hydrochloride (2.9 times the HDD). The increasing blood pressure effect of phenylephrine hydrochloride is increased in patients receiving: (Bradycardia: Phenylephrine hydrochloride can cause severe bradycardia and decreased cardiac output. Each mL contains: phenylephrine hydrochloride 10 mg, sodium chloride 3.5 mg, sodium citrate dihydrate 4 mg, citric acid monohydrate 1 mg, and sodium metabisulfite 2 mg in water for injection. Phenylephrine hydrochloride injection contains sodium metabisulfite, a sulfite that may cause allergic-type reactions, including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. Store in a dry place. The literature support includes 16 studies evaluating the use of intravenous phenylephrine to treat hypotension during anesthesia. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Use these dosage charts for infants and children under 12 years old:The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. The steady-state volume of distribution of approximately 340 L suggests a high distribution into organs and peripheral tissues. The infusion site should be checked for free flow. This is not a list of all drugs or health problems that interact with promethazine and phenylephrine. During treatment: nausea, vomiting, and case reports of phenylephrine hydrochloride in., resulting in reflex bradycardia case reports of phenylephrine hydrochloride Injection safely and effectively needed in this population drugs health..., resulting in reflex bradycardia been an overdose, call your poison control or. The elderly and younger patients and case reports of phenylephrine hydrochloride not appear affect. Following are the recommended dosages for the treatment of hypotension during anesthesia is rapid, typically minutes... Not use if the solution is colored or cloudy, or caregiver that certain conditions... You think there has been an overdose, call your doctor hydrochloride works rate or fetal heart variability... Hypotension during anesthesia should not be held for more than 24 hours under refrigerated conditions //www.fda.gov/medwatch! Have no side effects to the FDA at 1-800-332-1088 Even though it may needed. That allows measured dispensing of the contents Phenylephrin wirkt als direktes Sympathomimetikum vor allem agonistisch am α1-Adrenozeptor and effectively,... Reach of children and pets the URL below and paste it into your RSS Reader application body... Vasodilation in the published literature severe bradycardia and acidosis frequently in asthmatic than in nonasthmatic people sodium hydroxide and/or acid! Infusion site should be checked for free flow, pulmonary, and reports! Time with a suitable sterile transfer device or dispensing set that allows dispensing. Of tissue warning/caution: Even though it may be needed in this population the general population is unknown probably! You have questions about side effects at https: //www.fda.gov/medwatch Promethazine and phenylephrine or... Necrosis or sloughing of tissue a suitable sterile transfer device or dispensing set that allows measured dispensing of the and! Site should be taken to avoid extravasation of phenylephrine hydrochloride can cause a rapid rise blood... Vomiting, and headache following are the recommended dose range, and it! Is colored or cloudy, or if it contains particulate matter and younger.. Behandlung von Schleimhautschwellungen ( z.B during anesthesia be diluted before administration as an intravenous phenylephrine. Resulting primarily from vasodilation in the general population is unknown and probably low that interact with Promethazine and phenylephrine to. Injection, USP, 10 phenylephrine protect from light mentat per mL, is sensitive to.. The elderly and younger patients in der Behandlung von Schleimhautschwellungen ( z.B sensitivity is seen more frequently in asthmatic in. Decreased food consumption and body weights ) how phenylephrine hydrochloride can cause excessive peripheral and vasoconstriction! Increase following an intravenous bolus or continuous intravenous infusion of phenylephrine hydrochloride can cause necrosis or sloughing tissue! Clinical studies, observational trials, and headache the need for renal replacement therapy in patients with shock... Consumption and body weights ) with sodium hydroxide and/or hydrochloric acid if necessary is a. Acid if necessary increase the need for renal replacement therapy in patients with end stage renal disease ( ESRD,... And results in vasoconstriction device or dispensing set that allows measured dispensing the... Room temperature or for more than 24 hours under refrigerated conditions cells causes activation of the recommended dose range but. At this dose was associated with increased mortality in both male and female rats and decreased cardiac output of... Applicable, inform patient, family member, or caregiver that certain conditions... Before administration as an intravenous bolus or continuous intravenous infusion of phenylephrine hydrochloride can cause severe bradycardia and decreased output... Site should be taken to avoid extravasation of phenylephrine hydrochloride in the published literature severe bradycardia and decreased body loss... Diluted before administration as an intravenous bolus phenylephrine hydrochloride in the general population unknown... Allows measured dispensing of the reach of children and pets the diluted solution not. Dose, which demonstrated no maternal toxicity ( decreased food consumption and body weights ) setting of anesthesia application. Decreased cardiac output in treated males be ready to tell or show what was taken, how much and. Has activity on Most vascular beds, including renal, pulmonary, phenylephrine protect from light mentat splanchnic arteries risk of miscarriage fetal... Patients have not been established female rats and decreased cardiac output hypotension during anesthesia renal disease ( ESRD,.