Because of the potential for arthropathy and other serious toxicity in the nursing infant, breast-feeding should be discontinued during treatment with ofloxacin (see section 4.3).Since there have been occasional reports of drowsiness/somnolence, impairment of skills, dizziness/vertigo and visual disturbances, which may impair the patient's ability to concentrate and react, and therefore may constitute a risk in situations where these abilities are of special importance (e.g. Available for Android and iOS devices. Peritoneal dialysis and CAPD are not effective in removing ofloxacin from the body. Ofloxacin crosses the placenta and levels reached in the amniotic fluid are about 30% of the maximal concentrations measured in maternal serum.This medicinal product does not require any special storage conditions.Aluminium PVC/PVDC blisters and polypropylene bottles with polyethylene tamper evident closure (with optional polyethylene ullage filler).Obtainable in the following pack sizes: 3, 5, 6, 7, 8, 10, 12, 14, 16, 20, 24, 30, 50, 100, 250 tablets.Building 4, Trident Place, Mosquito Way, Hatfield, Hertfordshire, AL10 9ULTo bookmark a medicine you must sign up and log in.To view the changes to a medicine you must sign up and log in. Since hypoglycaemia is then more likely to occur, close monitoring of blood sugar levels is recommended in such cases.Based on a limited amount of human data, the use of fluoroquinolones in the first trimester of pregnancy has not been associated with an increased risk of major malformations or other adverse effects on pregnancy outcome. This website also contains material copyrighted by 3rd parties. Clipboard, Search History, and several other advanced features are temporarily unavailable. We comply with the HONcode standard for trustworthy health information - Cases of hypoglycaemic coma have been reported. The two main metabolites found in the urine were N-desmethyl-ofloxacin and ofloxacin-N-oxide. Dosages require adjustment in patients with severely abnormal liver or kidney function. The pharmacokinetic profile or ofloxacin shows a rapid gastrointestinal absorption and high concentrations are achieved in most tissues and body fluids. Up to 400 mg may be given as a single dose, preferably in the morning. In some cases these have progressed to suicidal thoughts or self-endangering behavior including suicide attempt, sometimes after a single dose of ofloxacin (see section 4.8). Please enable it to take advantage of the complete set of features! Patients should be advised to stop treatment and contact their doctor if signs and symptoms of hepatic disease develop such as anorexia, jaundice, dark urine, pruritus or tender abdomen (see section 4.8).Due to possible increase in coagulation tests (PT/INR) and/or bleeding in patients treated with fluoroquinolones, including ofloxacin, in combination with a vitamin K antagonist (e.g. The daily dose should be adjusted in elderly patients based on creatinine clearance (see section 4.2). Due to E. coli or K. pneumoniae: 200 mg PO q12hr for 3 days. Usual Adult Dose for Urinary Tract Infection 200 mg orally every 12 hours for 10 days Use: For the treatment of complicated urinary tract infections due to E coli, K pneumoniae, P mirabilis, C diversus, or P aeruginosa Usual Adult Dose for Prostatitis Therefore if ofloxacin has to be used in these patients, potential occurrence of haemolysis should be monitored.In patients treated with ofloxacin, determination of opiates or porphyrin levels in urine may give false-positive results. 400 mg PO single dose. Preclinical data from conventional genotoxicity studies reveal no special hazard to humans, carcinogen potential has not been investigated.Ofloxacin has no effect on fertility, peri- or postnatal development, and therapeutic doses did not lead to any teratogenic or other embryotoxic effects in animals. warfarin). 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