Histamine and collagen synthesis in keloid and hypertrophic scar. A fibroproliferative skin disorder hypothesis based on keloid findings. J Surg Res. Int J Dermatol. Akaishi S, Akimoto M, Ogawa R, et al. The most popular methods are direct surgical excision with postsurgical radiotherapy, cryotherapy, and laser therapy. 1985;82:5935–593921. Gallant-Behm CL, Hildebrand KA, Hart DA. Total management of a severe case of systemic keloids associated with high blood pressure (hypertension)—clinical symptoms of keloids may be aggravated by hypertension. 800-638-3030 1997;272:7127–713136. Fas-mediated apoptotic signal transduction in keloid and hypertrophic scar. The pathogenesis of these pathological scars involves cellular and ECM components in both the epidermal and dermal layers that are regulated by a wide array of interfering factors in the inflammation, proliferation, and remodeling phases. Wound Repair Regen. Aggarwal H, Saxena A, Lubana PS, et al. J Nippon Med Sch. Your Email: 2009;9:825. Dermatol Surg. Your Email: Int Wound J. BioDrugs. Janssen de Limpens AM, Cormane RH. Operating on a keloid usually stimulates more scar tissue to form, so people with … Wound Repair Regen. Martin-García RF, Busquets AC. The efforts to understand the pathogenesis of these scars are complicated further by the fact that the clinical diagnosis does not always correlate with the histological diagnosis. Histopathological differential diagnosis of keloid and hypertrophic scar. Data is temporarily unavailable. Lee JY, Yang CC, Chao SC, et al. This website uses cookies. 1996;106:476–48124. For immediate assistance, contact Customer Service: 2005;31(11, Part 1):1394–139861. 19962nd ed. Niessen FB, Schalkwijk J, Vos H, et al. A recent study showed that keloid-derived mesenchymal-like stem cells isolated from keloid scalp tissues could differentiate into adipocytes, osteoblasts, chondrocytes, smooth muscle cells, and angiogenic endothelial cells.In summary, HSs and keloids are the result of aberrant wound healing. The sebum or sebocyte hypothesis is particularly attractive as it explains the distribution and behavior of keloids. Other approaches are based on cytotoxic agents such as bleomycin-puncturePathologists and surgeons share a number of questions and interests regarding pathological scars: (1) Can a deeper understanding of aberrant scar pathogenesis be obtained by comparing pathological scars to local tumors such as basal cell carcinomas? Ogawa R, Okai K, Tokumura F, et al.  If so, the larger scar would be classified as a keloid. Please try after some time.Your message has been successfully sent to your colleague.Some error has occurred while processing your request. Keloids are frequently seen on the anterior chest and scapular regions but rarely on the scalp and anterior lower legs; this pattern correlates closely with the frequencies with which these body regions are subjected to local physical tension or movement.Endocrinology-based theories suggest that pathological scarring may be caused by physiological hyperactivity of the sebaceous gland. Hypertrophic scars and keloids are skin fibrotic conditions that can be caused by minor insults to skin, such as acne or ear piercing, or by severe injuries such as burns. Am J Pathol. Pistorio AL, Ehrlich HP. Wound Repair Regen. J Immunol. J Cell Biochem. 1985;121:995–99927. Med Hypotheses. Abergel RP, Pizzurro D, Meeker CA, et al. Collagenase production is lower in post-burn hypertrophic scar fibroblasts than in normal fibroblasts and is reduced by insulin-like growth factor-1. Differences between keloids, hypertrophic scars and normal scars include distinct scar appearance, histologic morphology and cellular function in response to growth factors. Keloids are rare in parts of the body that lack sebaceous glands, such as the palms and soles; they are also rare in animals that lack sebaceous glands. In particular, the significant roles of the extracellular matrix (ECM) and the epidermal and dermal layers of skin in scar pathogenesis are examined. 2004;202:121–12912. Friedman DW, Boyd CD, Mackenzie JW, et al. Arch Dermatol Res. New York Plenum Press:3–506. J Immunol. hey everyone! 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