The manager (been at this store for 10 years, total time of 17 years with the company) just cleared the interaction and told me that he doesn't care about any interactions unless they are Level X or so on any of the major databases. Take 200 Mg Toprol (metoprolol) Xl and Digoxin 0.125 Mg daily. Finally, a wise cardiologist took me off the time release and put me on the 2x a day dosage of the tartrate and my blood pressure has been really good since then. The heart rates over 100bpm are still high if resting heart rates.This problem mandates a real-time (face-to-face) meeting with a doctor. I thought maybe by switching to the brand name I could fix it but after several months on it found out AstraZeneca doesn't even make it anymore so I was paying 6x as much for, basically, the generic rubbish. You can find out drug interactions, minor or serious, reported by people like you. Try searching the No known alcohol/food interactions. Be aware, check on drug interactions yourself. View side-by-side comparisons of medication uses, ratings, cost, side effects, interactions and more.View side-by-side comparisons of medication uses, ratings, cost, side effects, interactions and more.This drug has caused edema in the lower legs since I have been using it, very painful when I put a finger for pressure on my skin from the knees down to the feet. If it continues for a long time, the heart and arteries may not function properly. Metoprolol is a selective beta-blocker at dosages usually prescribed to lower blood pressure or relieve the symptoms of angina. I am now in the process of doing research to prove my point. It can also be used for the preparation of certain medical tests (e.g., colonoscopy), before and after surgery, and in other situations where a bowel movement to required. you should not be using the medicine.I strongly urge you curtail alcohol consumption sharply. That should only be taken once a day. Due to all of the issues this has caused I've lost a bunch of weight and am exercising and on a low salt diet.