Follow all instructions closely. Therefore, there are no data which demonstrate that this dose is as effective as or is safer than the 200 mg daily dose in this patient population.Prophylactic dosing should be started in anticipation of an influenza A outbreak and before or after contact with individuals with influenza A virus respiratory tract illness.Amantadine Hydrochloride Tablets should be continued daily for at least 10 days following a known exposure. Do not swallow the ODT tablet. After single dose administration of 25 mg to 75 mg to 7 healthy, elderly male volunteers, the apparent plasma clearance of amantadine was 0.10 ± 0.04 L/hr/kg (range 0.06 to 0.17 L/hr/kg) and the half-life was 29 ± 7 hours (range 20 to 41 hours). Chronic Fatigue Syndrome. Read all information given to you. Considering NMS as a possible diagnosis and ruling out other acute illnesses (e.g., pneumonia, systemic infection, etc.) Select one or more newsletters to continue. See below for a comprehensive list of adverse effects. Drug class (es): adamantane antivirals, dopaminergic antiparkinsonism agents. Call your doctor for medical Common side effects of Emsam include: application site reaction and insomnia. for Parkinson's disease.Coadministration of quinine or quinidine with amantadine was shown to reduce the renal clearance of amantadine by about 30%.The concurrent use of amantadine hydrochloride with live attenuated influenza vaccine (LAIV) intranasal has not been evaluated. Amantadine hydrochloride is a stable white or nearly white crystalline powder, freely soluble in water and soluble in alcohol and in chloroform.Amantadine hydrochloride has pharmacological actions as both an anti-Parkinson and an antiviral drug.Each tablet intended for oral administration contains 100 mg amantadine hydrochloride and has the following inactive ingredients: microcrystalline cellulose, sodium starch glycolate, povidone, FD&C yellow #6 aluminum lake and magnesium stearate.Antiviral Activity: Amantadine inhibits the replication of influenza A virus isolates from each of the subtypes, i.e., H1N1, H2N2 and H3N2. Data from earlier animal studies suggest that amantadine hydrochloride may have direct and indirect effects on dopamine neurons. Symmetrel; Descriptions. However, such patients should be supervised closely by their physicians.Patients initially deriving benefit from Amantadine Hydrochloride Tablets not uncommonly experience a fall-off of effectiveness after a few months. All drugs may cause side effects. Hyperthermia has also been observed in cases where a drug overdose has occurred.There is no specific antidote for an overdose of amantadine hydrochloride. of age: The total daily dose should be calculated on the basis of 2 to 4 mg/lb/day (4.4 to 8.8 mg/kg/day), but not to exceed 150 mg per day.9 yrs. However, it has not been demonstrated that a 100 mg daily dose is as effective as a 200 mg daily dose for prophylaxis, nor has the 100 mg daily dose been studied in the treatment of acute influenza illness. Pharmacology, adverse reactions, warnings and side effects. Call your doctor or get medical Amantadine Hydrochloride Tablets should be held constant at 100 mg daily or twice daily while the daily dose of levodopa is gradually increased to optimal benefit.When Amantadine Hydrochloride Tablets are added to optimal well-tolerated doses of levodopa, additional benefit may result, including smoothing out the fluctuations in improvement which sometimes occur in patients on levodopa alone. Drug overdose has resulted in cardiac, respiratory, renal or central nervous system toxicity. The half-life was 17 ± 4 hours (range: 10 to 25 hours). Pulmonary edema and respiratory distress (including adult respiratory distress syndrome – ARDS) have been reported; renal dysfunction including increased BUN, decreased creatinine clearance and renal insufficiency can occur. If dizziness or lightheadedness occurs, notify physician.Notify physician if mood/mental changes, swelling of extremities, difficulty urinating and/ or shortness of breath occur.Do not take more medication than prescribed because of the risk of overdose. Benefit may be regained by increasing the dose to 300 mg daily. Amantadine hydrochloride is a stable white or nearly white crystalline powder, freely soluble in water and soluble in alcohol and in chloroform. Amantadine systemic is used in the treatment of: ADHD. The 100 mg daily dose has not been studied in this pediatric population. If Amantadine Hydrochloride Tablets are used chemoprophylactically in conjunction with inactivated influenza A virus vaccine until protective antibody responses develop, then it should be administered for 2 to 4 weeks after the vaccine has been given. For all uses of this medicine (amantadine capsules and tablets): taken, how much, and when it happened. 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