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The most common causes are excessive weight loss, exercise, chronic illness, stress and medications. Local activation is identified by the initial signal peak, but this measure is less reliable than with unipolar electrograms if the signals are fractionated or have multiple components. Physical Dependence A withdrawal syndrome should rapidly ensue upon abrupt withdrawal of the drug, which, in most cases, serves as a strong stimulus to continue to self- administer the drug. Electro-anatomical mapping 15 are generated by computing the difference in the potential recorded between two closely-spaced electrodes. Because the electrical ac- tivity does not correspond to the potentials at the endocardial surface but in the blood pool, an inverse problem must be solved. Phar- macol Biochem Behav 84:555–567 Glazer G (1991) Atherogenic effects of anabolic steroids on serum lipid levels. 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